Aiming at the problems of poor universality and low efficiency of manual error adjustment of atmospheric pressure sensor for meteorological observation, an error self calibration system for error adjustment of target sensor is designed. The developed sensor error self calibration software cooperates with the self-designed multi-channel sensor converter, pressure controller and air pressure standard, which can complete the error automatic adjustment task of 8 channel air pressure sensors at the same time. In the actual test, the system completes the automatic error adjustment of 8-channel sensor within 1 hour. The absolute error value of each channel sensor after adjustment does not exceed 0.05 hPa, which is far less than the maximum allowable error of ±0.25 hPa and the error limit of ±0.30 hPa required by the specification. While improving the efficiency of sensor error adjustment, it is conducive to improve the quality of barometric observation data.