With the wide application of 1553B bus in the connection mode of distributed slave equipment in aviation system and ground vehicle system, it is particularly important to improve the design flexibility, reliability and certainty of test equipment in weapon equipment support system. Therefore, a design method and implementation of PXI bus test equipment based on 1553B bus architecture are proposed. The engineering application shows that it can meet the equipment testing requirements and has the characteristics of good scalability, real-time and reliability. It has a certain reference value for the equipment development in the field of weapon equipment testing.