Cabin pressure control is one of the key technologies that commercial aircraft manufacturers must focus on. The traditional PID pressure controller based on fixed parameters is difficult to adapt to the complex and changeable environment inside and outside of the cabin, which seriously affects the passenger comfort and gives a serious threat to the flight safety. The mathematical model of cabin and exhaust valve are established and simplified. A fuzzy adaptive PID controller is designed. The simulation results show that the fuzzy adaptive PID controller is much more stable than the traditional PID controller when the cabin model parameters changed. It will not only increase passenger comfort and ride experience, but also avoid fatigue damage to aircraft structure caused by pressure alternating actions. This will help to improve flight safety and enhance the market competitiveness of aircraft.