Flight load test based on pressure distribution test is of great significance for aircraft aerodynamic design verification and structural strength assessment, the accuracy of the flight pressure module test directly affects the test results of the subject, according to the demand of flight test, research on the calibration of test system was carried out based on the principle of pressure module, and a multi-channel calibration method was proposed. Ground calibration experiments show that the flight test module"s test accuracy is better than 0.05%, and the uncertainty is 0.00039 psi (k=1.96). It has been verified by flight test that the calibrated flight pressure measuring module works stably and provides accurate test data for the surface pressure distribution test of a certain structural part.