In order to ensure the accuracy of receiving data and improve the automation level of testing and calibration, this paper designs the software of automatic calibration system for signal receiver based on C# and SQL Server. Design system program based on multi-threading to improve the efficiency of test calibration. Drawing test data waveform based on double buffer technology solves the problem of waveform display flash screen. SQL Server database is used to store test data and instrument control instructions to achieve efficient data storage and management. The automatic generation of calibration certificate and original record is realized by using the automatic generation technology of test report. The design of the automatic calibration system has a strong application value for improving the calibration efficiency of signal receiver and enhancing the measurement support ability of equipment.