Abstract:it introduces the current status of package and transport of aviation products, and the advantages and disadvantages of different packaging ways. During the course of package and transport of aviation products, there are higher standards on the antiseptic property and strict requirements on the overall sizes of the packaging box, so that here it puts forward the design concept with irregular shape and internal pressure mental packaging box, and also it has research on the virtual simulation experiment in the aspects of structural intensity and reliability. It also makes exploration on the methods by applying the design standards of pressure vessel in the design of structural intensity; in accordance of the actual transport state, it simulates the standards for the simulation experiment on the design load of packaging box, and has intensity check on the state of every simulation experiment of packaging box during the total course of transport; it completes the intensity analysis of the packaging box, and puts forward principles on the structural design of internal pressure mental packaging box and structural optimization scheme for specific and classical part, so that it can provide some opinions and references for the structural design of such kind of products, making of virtual simulation experiment, and selection of parameters.