In view of the lack of engineering application background and poor visibility in PLC teaching, configuration software is introduced into PLC teaching to build a simulation system. This paper introduces the configuration interface design and PLC programming of elevator control system, and constructs six 10-floor elevator control system based on Botu V14 by S7-1200 PLC and PC. This system can directly simulate the elevator control process, carry out real-time monitoring, and have the functions of fault processing, alarm and abnormal status display. The results show that by combining the configuration simulation software technology with PLC teaching, the debugging and simulation of PLC program can be realized without the actual physical control object, which can reduce the cost and enrich the teaching content and enhance the teaching vitality to the greatest extent.