Reconnaissance and strike integrated unmanned aerial vehicle (UAV)has the characteristics of long-endurance and multitask profile. For the problem that using fixed control parameters is difficult to meet the flight quality within full envelope, the linear-time-variable mode was established and the influences of airspeed, altitude and mass were studied to the flight quality. Both longitudinal and latitudinal control laws for the short period mode were designed and the gain-schedule table was obtained at the typical working points of the sample UAV. At last, the global gain-schedule controller was designed by means of parameter-fitting. The simulation results show that the variable gain controller can effectively improve the flight quality the within the full envelope and the operational performance of UAV.