With the continuous improvement of real-time requirement of power grid monitoring system, a multi-strategy dual-machine hot standby method is proposed to avoid service interruption caused by network environment and program faults and ensure the uninterrupted operation of real-time application services. By using HeartBeat protocol between master and standby nodes and time synchronization mechanism with database, the dual heartbeat detection of running state can be realized to avoid the problem of split-brain. Then the service takeover can be completed by using IP multiple checks of nodes, and the smooth switching between master and standby can be realized. This method is simple and efficient without any additional system configuration, and its stable performance is verified in practical application.