To achieve practical application of pneumatic waste collection system, the design and test of valves control strategy are important. Analyze the working process of the system, try to present operational factors of system and create the numerical model. The project defines the essential control strategy as “from the bottom up”. There are three control schemes including single loop evacuation strategy and the three layers unit is the best, which can be proved by numerical simulation. In this way, the system can achieve less valves opening, less system equipment cost and more safety.