The requirement of lightweight composite materials has been continuously improved in engineering application, in order to meet required by material strength and the fatigue life of the engineering application and achieve the purpose of structure mass reduction, the optimization method of composite laminated structure under the influence of strength and fatigue life is studied, and the optimization method of composite laminated structure based on parametric finite element technique and genetic algorithm is proposed. According to the characteristics of the composite laminated structure layer parameters belong to discrete variable, the genetic algorithm is transformed into a combined integer coding. In order to get the optimal solution quickly and accurately, elitism preserving strategy, crossover and mutation adaptive degree strategy are put forward. Finally, to verify the proposed method, the co-simulation based on the Visual Studio and ANSYS has been carried out, the simulation results show that the composite layer of the optimized structure can not only meet the constraints of strength and fatigue life, and the quality is reduced to 56.2% of initial mass, the optimization effect is obvious, which indicates that the optimization method of composite laminated structure based on parametric finite element technique and genetic algorithm is feasible.