In view of the low efficiency and poor anti-interference ability of the mechanical transmission press, a design method of electro hydraulic servo automatic control system for mechanical transmission pressure based on TMS320LF2407A is presented. For the hardware part of the system, PLC collects the pressure signal, and the power module adopts the voltage regulator to complete the DC/DC conversion of 12~5 V. The oscillator is used as the oscillation source and the closed loop is combined to complete the design of the clock module. The software part of the system controls the actuating element of the mechanical variable speed press according to the position type PID control algorithm, and completes the design of the software. The experimental results show that the designed control system has good stability and good anti-interference ability.