This paper introduces the design of temperature measuring and controlling system based on 1553B bus which use for space camera. The circuit measure the resistance of thermistor through resistance divider, temperature compensation part use the PID control method. This paper introduce the principle of the system, the realization of the circuit and software flow first, then analyses the temperature measurement’s error source and the method to correction, finally list the experimental data and came to the conclusion that the temperature measurement accuracy is better than 0.1℃, the temperature control accuracy is better than 0.3℃.