In order to solve the test requirement of real-time data telemetry of high speed avionics bus in flight test, the test technology of high speed avionics bus data acquisition and real-time telemetry is studied. In the face of the new bus architecture and massive real-time data transmission, the traditional bus testing technology can not meet the new test requirements, the test system of data acquisition and telemetry transmission of high speed avionics bus is designed. The high speed bus data is fused to the network data acquisition technology and the digital telemetry technology. The test results show that this scheme can accurately and effectively complete the airborne avionics bus high-speed data acquisition and real-time telemetry transmission, the successful application of this project, provides an important reference value for the future high speed bus data related test.