In the process of research for hypersonic vehicle, the great long distance can be reached within short times due to its high flight speed and altitude. We need project the whole flight path in order to meet the operation plan. The most important part is the guidance problem of ascent stage. This thesis takes X-33 aircraft model as the research object, and put forward the ascent closed-loop guidance of hypersonic vehicle based on particles swarm methods. It can correct the flight path in real time and lead the vehicle to the target location. Then simulate the reliability of this method. The result indicated that this closed-loop guidance method based on particle swarm has better accuracy, and the physical conception is specific. This method can satisfy the demand of closed-loop for the ascent of hypersonic vehicle.