Aiming at the problem of how to ensure the accuracy and feedback satisfaction of the users' personalized travel demand, the collaborative management technology of cloud computing in the tourism supply chain is established. Firstly, the characteristics of the tourism industry and the characteristics of personalized service are analyzed, and the characteristics of the service time, the cost of tourism and the quality of the user experience are considered. Secondly, cloud computing presents a collaborative management framework based on Optimization of personalized travel demand and solve the differential effects on the tourism supply chain. Compared with the non-cooperative management scheme, the proposed scheme of collaborative management will interfere with individual differences on tourism supply chain management to reduce 25%, protect the user satisfaction at a higher level.