In order to solve the actual problems arose with the lateral deviation braking system, a mathematical model of lateral deviation control of Unmanned Aerial Vehicle was built on Simulink, the correction algorithm of Unmanned Aerial Vehicle moving on the ground was designed and its correction parameter was programmed to the best by the front wheel steering, the nose wheel string, the difference in combined brake model and the rudder to control the lateral deviation correction, and also by the application of the full optimization process of genetic algorithms. By applying the control method of genetic algorithms, it is possible to achieve certain level of deviation correction in the Unmanned Aerial Vehicle’s moving on the ground and can thus improve the utilization of runways.