In order to promote the implementation of the Industrial 4.0 and the “Chinese manufacture 2025” in the field of manufacturing, and establish the effective level of control and equipment in the intelligent manufacturing system. It also promotes the combination of workshop status data and the intelligent manufacturing technology flow. This article presents a method of workshop status detection and technology flow control based on intelligent instruments and intelligent inspection technology. This article also made discussion about the new application mode in the intelligent manufacturing system of intelligent instruments and intelligent inspection technology, the innovative practice has made with the actual project of digital production line transformation,and pointed out the development direction of intelligent instrument and intelligent inspection technology which can satisfy the requirement of intelligent manufacturing system. It has been verified by the actual projects that the use of intelligent instruments and intelligent inspection technology can effectively improve the process of data acquisition and intelligent status perception, it can provide the data resource for intelligent decision making in the technology process, intelligent instruments and intelligent inspection technology will be the key foundation of the intelligent manufacturing system.