Dissolved oxygen (DO) concentration has long been recognized as a important controlled variable in the activated sludge wastewater treatment processes, and the fluctuation of Do concentration around the set-point and accumulated air consumption are taken as important performance parameters. In this paper, gain-scheduling control methods for DO concentration, where set-point value for DO concentration is considered as a scheduled variable, is presented. Simulations show that the presented gain-scheduling control method has obvious advantages over conventional control methods such as On-Off control and PID control in the energy consumption and control precision.