There are poor measuring precision and operability in the traditional missiles’ centroid localization equipments.So based on the research on centroid localization principle,the projectile bodies’ centroid localization models are established by selecting the moment calculation reference points logically;Depending on the measuring and controlling platform of the interpolating VI of DAQ based on PCI bus,emphasizing the design idea of versatility,accuracy and high efficiency,the system’s general design proposal is framed,and the technology and engineering of missiles’ mass measurement and centroid localization are studied and implemented.The application showed that:the system is universal measuring platform of mass measurement and centroid localization of many missiles and cylindrical workpieces,and can satisfy the needs of missiles control research and assembly craft.