From two good qualities of the Agent - autonomy and collaborative, the coordination of multi-Agent thought flying communication technologies are researched in multi-UAV coordinated flight. Based on the characteristics of multi-UAV coordinated flight, the communication protocols of multi-Agent coordinated flight , information transmission between multi-Agent and information share model are designed. The process of information transmission between MAS is analyzed. Finally, this paper introduces and analyzes building form of MAS coordination communication through an example, and the data communication for multi-UAV coordinated target position is realized. Actual flight experiment results show that the communication mechanism can control multi-UAV flying at the same time, improve the communication efficiency, proves the feasibility and validity of the method.