As the complexity of missile increases continually, the communication between the devices in the missile becomes more and more frequent, which requires faster and faster transfer speed of 1553B bus. The traditional 1 M1553B bus is not fast enough to transfer information in modern aeronautics, astronautics and ground vehicle system. High speed 1553B bus appears at present. This paper researched the communication character of high speed 1553B, and proposed two design approaches of interrupt and query for Remote Terminal (RT) software based on the demand of different RTs in the missile. The two approaches were successfully utilized in the RTs of one series missile, and passed various tests. during the development stage, the experimental results demonstrated that the interrupt and query methods met the requirements of the different RTs, which could be used in other missiles.