For adapting to the increasing demand on the autonomy,rapidity,reliability and safety of the pressurization control systems,especially for the cryogenic ones,design a double-loop pressurization system based on MODBUS and EGD,by using of the most popular technology in current industrial control field – PLC. MODUS has two protocols about TCP/IP and serial communication link,while EGD has the advantages of high speed and efficiency. It is proven that the system can not only effectively avoid network fault on the boosting process effect to increase the automatic control ability,but also enhance the safety of the pressurization process by using a series of reliability designs on software and hardware.