Since there are many kinds and huge quantity of spacecraft interfaces, specialized interfaces have to be designed for traditional testing systems. This is kind of heavy workload, and it lacks of universality. In order to improve the efficiency of system design, a design method of high performance general digital interface module based on PXI bus is presented in this paper. On the basis of describing framework of the module, the design principles of main board and interface are introduced in detail. The software design strategy and definition of user interface are also provided. This module is capable of sending and receiving massive data via multi-channels. And it has been successfully applied in several models of testing systems. Practical application verifies that this module is able to meet the requirements of testing systems.