The guided tracking characteristic of air-to-air missile is directly influence the accuracy of attacked a target. Design a guided stability tracking controller with inverse dynamic system method of nonlinear controlling was presented for the characteristic of nonlinear and strong coupling of control system of air-to-air missile. And based on the centroid of missile movement model was established and simulated, compared the results of the simulation with interference and non-interference. The simulation result show that guided tracking control system is quick convergent with anti-interference performance, and can keep stability track.