Abstract:The traditional model of multiphase Chan-Vese is easy to cause empty phase problem during the multi-region segmentation,To solve this problem,it proposes a improved Chan-Vese model of medical image segmentation algorithm combined with mathematical morphology in this paper.The algorithm integrates Chan-Vese model, mathematical morphology, complex multiphase level sets segmentation algorithm, first, through iterative etching operation to extract the outline of the medical image, and then the medical image is segmented by the Chan-Vese model based on the complex multiphase level sets, finally the medical image is dilated iteratively by using morphological dilation to restore the image.The experimental results and analysis show that this algorithm solves the multi-regional medical image segmentation problem well, and reduces the empty phase, and has a very good segmentation effect on the edge of the image.