Aiming at the deficiency of simulation platinum thermal resistance in current market, we design a 24 channel high precision platinum resistance breadboard—PXI5440 using digital potentiometer and precision resistance.We analyse the error on the basis of error propagation, and the results confirmed that:The replacement of precision resistance can adjust the output range of the platinum resistance, and it will not affect the output precision of the resistance; The greater the output resistance, the lesser it will affect on the precision of output resistance, and the absolute error of the output resistance will decrease. We give the driving function algorithm and the actual measurement results,which prove the correctness of the design ideas and theory. Compared with the existing products on the market, the breadboard of platinum thermal resistance in this paper,has the characteristics of low price、multi-channel and high precision.