【】In multi-user detection of MIMO-OFDM system, the detection order and error propagation are less consideration in traditional interference cancellation algorithm. Aiming at these shortcoming, a novel fast recursive successive interference cancellation multi-user detection algorithm with inverse detection order is presented. In the algorithm, the detection order is inversed and it chooses the user’s data with the maximum correlation to detect at last and prevent the error propagation efficiently; the MMSE filter matrices and the detection order are successively computed from the previously obtained filter matrices, so that the algorithm complexity is reduced significantly. Theory analysis and simulation shows that the proposed detection algorithm has the lower computational complexity and better performance.